Assessment of Matrix Metalloproteinases-1 in Septic Acute

The extracellular matrix (ECM) does not simply maintain the form of tissues; it is a dynamic factor that plays a major role in cell function. Matrix metalloproteinases (MMPs) are the most important enzymes in ECM degradation, and their activity is controlled strictly by specific inhibitors, that is tissue inhibitors of metalloproteinase (TIMPs). We assessed the clinical course of changes in ECM-degrading enzymes TNF-a, IL-6, IL-8, and nitrite/nitrate (NOx) in the blood of two septic acute respiratory distress syndrome (ARDS) patients. Negative correlation was found between the PaO2/FIO2 ratio (P/F ratio) and MMP-1, but positive correlation was found between the P/F ratio and both the TIMP-1/MMP-1 ratio and MMP-1 • TIMP-1 complex level. TIMP-1 was consistently maintained at high levels. These results suggest that both MMP-1 and TIMP-1 may be involved in septic ARDS, and that the balance between MMP-1 and TIMP-1 is important.