Rescue therapy with high-frequency oscillatory ventilation in severe acute respiratory distress syndrome

There is emerging evidence on the effectiveness and safety of high-frequency oscillatory ventilation in patients with acute respiratory distress syndrome. We described two patients with severe acute respiratory distress syndrome in whom low tidal volume ventilation with conventional mechanical ventilator failed to achieve physiological improvement. The initiation of high-frequency oscillatory ventilation as rescue therapy in these patients resulted in remarkable improvement in oxygenation and hypercapnia.