Authors:

 In Original Article

Objectives: To determine the role of the end-inspiratory transpulmonary pressure as an indicator of the lung stress in the disorder of chest wall mechanics, in pig model.
Design: Experimental study.
Setting: Department of Surgery and Radiology, Veterinary Medicine, Bogor Agricultural Institute.
Subjects: Nine healthy mixed breed domestic piglets were divided into 2 groups: intervention/splinted chest wall (n=5) and control (n=4).
Intervention: This study had approval from Animal Care and Use Committee. The care and handling animal were accorded with National Institute of Health guideline. All of animals were anesthetized, muscle paralyzed and bronchial lavage with warm saline, in supine position. Both group were mechanically ventilated and underwent lung recruitment using incremental-decremental technique. Chest wall splinting was conducted in intervention group while the control group did not.
Measurement and Main Results: Transpulmonary pressures calculated after measure the esophageal pressure using esophageal catheters. The transpulmonary pressure in intervention group prior to (1.80±2.28 cmH2O) and after (11.00±5.83 cmH2O) recruitment maneuver, increased significantly compared with control group prior to (1.25±3.68 cmH2O) and after (3.25±1.18 cmH2O), with p value 0.04. The difference of mean end-inspiratory transpulmonary pressure (Ptp plateau) between intervention and control group was significant (p=0.05). ∆Ptp plateau values have strong correlation with the increasing of chest wall elastance (Ecw) in the intervention group (p=0.001, R2=0.8) and control group (p=0.007, r=0.7), as well as the correlation of ∆Ptp plateau with decreasing the lung compliance (Cl) (p=0.05, r=0.8). The strong correlation between ∆Ptp plateau and ∆Paw (p=0.001, r=0.7) in the intervention group showed the potency of the transpulmonary pressure to reflect the real lung distending pressure and the lung stress.
Conclusions: The measurement of end-inspiratory transpulmonary pressure is reliable as an indicator of lung stress in disorder of chest wall mechanics.

Recent Posts
Contact Us

We're not around right now. But you can send us an email and we'll get back to you, asap.

Start typing and press Enter to search