Association of vitamin D plasma concentration with the severity of illness among children with sepsis treated in Pediatric Intensive Care Unit
Objective: To investigate whether vitamin D plasma concentration correlated with the severity of illness in sepsis children treated in a Pediatric Intensive Care Unit (PICU).
Design: This was a cross sectional study.
Settings: Pediatric Intensive Care Unit of Sanglah Hospital Denpasar, Bali, in May to November 2016.
Patients and participants: Samples were patients aged 28 days to 12 years who had sepsis or severe sepsis or septic shock and have been hospitalized in PICU. The subjects who met the inclusion criteria were divided into two groups based on the vitamin D status: normal and insufficient.
Intervention: The severity of illness of the patients in each group was measured using Pediatric Logistic Organ Dysfunction (PELOD) II and Pediatric Risk of Mortality (PRISM) III score. The demographic data, anthropometric status, and severity of the illness were taken from the medical records. The amount of sun exposure and patient nutritional intake were taken from questionnaires answered by the parents.
Results: A total of 48 patients were examined in this study. Bivariate analysis showed that vitamin D insufficiency was associated with a higher severity of sepsis based on the PRISM III (r=-0.44, p=0.006) and PELOD score (r=-0.5, p<0.001).
Conclusion: Vitamin D plasma concentration was negatively correlated with the illness severity in children with sepsis.