The effect of oral N-acetylcysteine on galectin-3 and global longitudinal strain in patients with acute myocardial infarction

Abstract

Objective: Galectin-3 (Gal-3) plays a big role in the development of cardiac fibrosis; however, its role in remodeling after acute myocardial infarction (AMI) has not received sufficient attention. Post-AMI measurements of global longitudinal strain (GLS) are beneficial in providing information about infarct area and remodeling. We aimed to determine the effect of N-acetylcysteine (NAC) on Gal-3 and GLS in AMI.

Design: This was a randomized, single-blind study with pre- and post-treatment evaluations performed from May 1 to August 31, 2018.

Setting: Dr. Moewardi Hospital, Indonesia

Patients: ST elevation myocardial infarction (STEMI) patients who received fibrinolytic therapy were randomly allocated to NAC and control groups.

Interventions: A total of 32 STEMI patients were administered fibrinolytic therapy (17 patients were administered standard therapy plus 600 mg NAC orally three times a day for 72 hours and 15 patients were administered standard therapy plus placebo as the control). Gal-3 samples were taken during admission and at 72 hours in both groups, while GLS measurement was only performed 72 hours after admission.

Measurements and results: Gal-3 levels in the NAC and control groups at admission were not significantly different; however, levels were significantly different after 72 hours (p=0.017). After comparing Gal-3 levels during admission and at 72 hours, the NAC group showed significant differences between Gal-3 levels at the time of admission and at 72 hours (p=0.0001); no difference was found in the control group. There were also significant intergroup differences in Gal-3 level changes (p=0.014). In the NAC group, a better and significantly different 72-h GLS value was obtained from that in the control group (p=0.023).

Conclusion: Supplementary therapy with NAC can reduce Gal-3 levels and GLS in AMI patients receiving fibrinolytic therapy.


Authors: Trisulo Wasyanto, Akhmad Jalaludinsyah, Ahmad Yasa

Correlation between zinc plasma level to inflammation response of patient with ventilator in pediatrics intensive care unit

Abstract

Objective: Critical conditions arise when there is a threat or ongoing organ failure that disrupts the balance of the body's oxygen and physiological needs. Patients often require help, such as endotracheal intubation procedures, mechanical ventilation, and renal or liver replacement therapy, in place of impaired organ function. Usually, complications are more common in children than in adults. Zinc is one of the micronutrients that plays a vital role as an antioxidant and the role of defense immune modulators against systemic inflammatory response syndrome (SIRS). Outcome patient with ventilator depends on SIRS response to the disease. Meanwhile the study about zinc supplementation in Pediatric Intensive Care Unit (PICU) is limited. The main objective of this study was to look at the correlation of plasma zinc levels with inflammatory responses in children of 1-12 years old with ventilator in pediatric intensive care unit.

Design and setting: This study was prospective study in Sanglah General Hospital, Denpasar and was calculated by Pearson analysis to determine the correlation of variables plasma zinc with levels of pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) and continued by general linier model analysis.

Results: More than 70% sample was insufficiency zinc for the first 24 hours and after 72 hours, respectively. Correlation between plasma zinc and pro-inflammatory cytokines were TNF-α; p<0.001 r: -0.91, and IL-6; p=0.013, r: -0.48 in 24 hours, and IL-6; p>0.05 r: 0.011, and TNF-α; p<0.01 r: 0.659 in 72 hours.

Conclusions: There were significant correlation in TNF-α and IL-6 measurement between zinc plasma insufficiency with pro-inflammatory cytokines in the first 24 hours and significant correlation in TNF-α in 72 hours. Therefore, zinc supplementation in 72 hours from patient admission to PICU may have important role to reduce morbidity in PICU.


Authors: Dyah Kanya Wati, Lanang Sidiartha, Ketut Tunas, Andrie Setiawan

Lactic acid’s role in sodium hypertonic lactic solution as a neuroprotector measured from the level of ATP, MCT-1 and necrosis area in intracerebral hematoma rats model

Abstract

Objective: To discover the role of hypertonic sodium lactate (HSL) as the energy source, which in turn will act as a neuroprotector, by measuring adenosine triphosphate (ATP) level, monocarboxylate transporter 1 (MCT-1) and the extent of the necrotic areas.

Design: This was an experimental study that used randomized post-test only control group design.

Setting: Experimental Animal Care Unit Universitas Gadjah Mada.

Patient and participant: 32 white mice of Rattus norvegicus.

Intervention: After the protocol of this study was approved by the research ethic committee, 32 rats were randomly divided into two groups: HSL group (n=16) and NaCl 3% group (n=16) as the control group. Both groups were anesthetized using conversion-dose pentothal.

Results: ATP level in HSL group was higher compared to the control group (p=0.031). MCT-1 in HSL group was also higher than the control group (p=0.010). Necrotic areas were less extensive in the HSL group than the control group (p=0.000). Lactate levels at minute 30 (T30) and minute 360 (T360) increased in the HSL group, while increasing in the control group up to T30, then decreased gradually until T360.

Conclusion: Exogenous lactate in solution has effect as a neuroprotective of brain in the intracerebral hemorrhage (ICH).


Authors: Hamzah, Nancy Margarita Rehatta, Tatang Bisri, Siti Chasnak Saleh, Arie Utariani

End-of-life care (EOLC) in Jordanian critical care units: Barriers and strategies for improving

Abstract

Background: End-of-life care (EOLC) is a pivotal element of work in ICUs and for critical care nurses, thus, it is considered one of the top research priorities recently as number of admission ICUs increasing and high percentage of deaths also.

Objective: This study was conducted to explore the obstacles of EOLC and strategies for improvement from nurses' perception.

Methods: The questionnaire, that was developed by Beckstrand and Kirchhoff (2005), was used to collect data from 163 critical care nurses from different hospitals.

Results: Two hundred questionnaires were distributed. One hundred and sixty-three questionnaires were completed and returned with response rate 81.5%. The majority of the participants were male nurse 104 (63.8%), with bachelor degree 153 (93.9%), working in adult ICU 105 (64.4%), as bedside nurse 141 (86.5 %). The highest obstacles from the nurses’ perception were family and friends who continually call the nurse wanting an update on the patient’s condition rather than calling the designated family member for information (mean=4.07). Furthermore, the highest three supportive behaviors from the nurses’ perception were physicians agreeing about direction of patient care (mean=3.96), family members accept that patient is dying (mean=3.94), and family designating one family member as contact person for the rest of the family (mean=3.89).

Conclusion: As the number of deaths is increasing in critical care units, the needs to understand how the EOLC is provided in these units. Identifying obstacles and supportive behaviours will assist the stakeholders and policymakers to set the action plans for improving the quality of EOLC.


Authors: Loai Abu Sharour, Maha Subih, Omar Salameh, Mohammad Alrshoud

Electrical cardiometry for non-invasive cardiac output monitoring in children with dengue hemorrhagic fever and shock in comparison between referral and non-referral

Abstract

Objective: Shock in dengue hemorrhagic fever (DHF) is mostly caused by plasma leakage. Hemodynamic monitoring is essential for improving the quality of management and the outcome. We sought to find the hemodynamic profile of dengue hemorrhagic fever children with shock.

Design: a cohort prospective study.

Setting: Pediatric Intensive Care Unit (PICU) at tertiary general hospital in Surabaya, Indonesia.

Patients and participants: Children <18-year-old admitted to the PICU with diagnosis DHF with shock.

Intervention: All patients underwent measurement of hemodynamic profile with electrical cardiometry ICON OsypkaTM after the first fluid resuscitation.

Measurements and results: There were 37 patients with DHF grade 3. All patients had normal blood pressure on first examination, with the mean of systolic and diastolic blood pressure were 82.5±9.21 mmHg and 51.8±16.32 mmHg, respectively. They had low stroke volume (66.7%), high heart rate (60.6%), low cardiac output (49%), and high systemic vascular resistance (55%). Mean resuscitation fluid volume was 35.30±31.99 ml/kg, where referral patient had significantly higher resuscitation fluid volume (49.45±39.46 ml/kg) than non-referral (19.75±0.60 ml/kg), p=0.002. Thoracic fluid content were significantly higher in referral (75%) than those in non-referral patients (16.7%), p=0.001.

Conclusion: After first fluid resuscitation, children with DHF grade 3 obtained normal blood pressure but still in hypovolemic state. Referral patients had higher fluid volume resuscitation and thoracic fluid content than those in non-referral.


Authors: Ira Dharmawati, Andri Kurnia Wahyudhi, Intani Dewi Syahti Fauzi, Arina Setyaningtyas, Dwi Putri Lestari, Neurinda Permata Kusumastuti, Abdul Latief Azis

The effectiveness of a short training course for emergency medicine residents to confirm tracheal tube placement by ultrasound

Abstract

Objective: The present study aimed to evaluate the performance of tracheal ultrasound by novice emergency medicine residents after participating in a short training course.

Methods: This was an observational prospective study conducted between July 2016 and September 2017 at three university-affiliated emergency departments in Tehran, Iran. Adult patients (over 18 years of age) who needed emergency intubation were included. Investigators were emergency medicine residents who did not have prior experience in tracheal ultrasound. Training course consisted of 40 minutes of theoretical education and three days of hands-on training. Immediately after intubation by treating physicians, two investigators evaluated the placement of the tracheal tube simultaneously. One investigator used tracheal ultrasound and the second investigator used quantitative waveform capnography. The registrant was a nurse who was asked to record the results of each investigator in the following format: 1. Correct tracheal intubation, 2. Esophageal intubation, and 3. Time spent to complete the evaluation. Finally, the ultrasound results were compared with those of capnography.

Results: Ninety patients were included in the study. Based on the capnography results, there were three (3.3%) esophageal intubations and 87 (96.6%) tracheal intubations.  Investigators reported the same results by tracheal ultrasound. The mean±SD time spent to complete the evaluation was 32±10 seconds for capnography and 48±15 seconds for tracheal ultrasound (p value of 0.0001).Conclusion: Emergency medicine residents with basic knowledge of ultrasound can learn tracheal ultrasound techniques through a short training course.


Authors: Mohammad Afzalimoghaddam, Kamal Basiri, Seyedhossein Seyedhosseini-Dvarani, Farideh Bagheri, Ehsan Karimialavijeh

Delirium in critically ill patients: incidence, risk factors and outcomes

Abstract

Objective: To determine the incidence, and evaluate the risk factors and outcomes of delirium in general Intensive Care Unit (ICU).

Design: Prospective cross-sectional observational study.

Setting: Teaching hospital in Kuala Lumpur, Malaysia.

Patients and participants: Patients ages of 18 and above admitted for more than 24 hours in general ICU were recruited into the study.

Measurements and results:The demographic data, predisposing and precipitating factors, and environmental factors were collected. Confusional Assessment Method (CAM-ICU) was done daily to assess delirium, when the patient had a sedation score of above Richmond Agitation and Sedation Scale (RASS) -3. Patients were followed up till discharged from ICU. Length of mechanical ventilation and length of ICU stay were recorded.

A total of 139 patients were recruited with overall incidence of delirium was 42%. Among patients who had delirium, 68% were of hypoactive delirium, 25% of mixed delirium and 7% were hyperactive delirium. The significant predisposing risk factors for developing delirium were age, higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, visual or hearing impairment, smoking, renal impairment, diabetes, and hypertension. The factors detected precipitating delirium were sepsis, use of vasopressors, renal replacement therapies, and acute respiratory distress syndrome (ARDS). The presence of catheters, higher Sequential Organ Failure Assessment (SOFA) scores, and abnormal urea and bilirubin levels further significantly increased risk of delirium. Environmental conditions increasing the risk of delirium included absence of daylight exposure and visible clocks, and use of physical restraints. As a result of delirium, patients had longer length of mechanical ventilation and ICU stay.Conclusions: Recognizing predisposing factors and optimizing the modifiable risk factors will improve the length of mechanical ventilation and ICU stay.


Authors: Lavitha Vyveganathan, Azarinah Izaham, Wan Rahiza Wan Mat, Shereen Tang Suet Peng, Raha Abdul Rahman, Norsidah Abdul Manap

Dispatcher-assisted cardiopulmonary resuscitation improves the neurological outcomes of out-of-hospital cardiac arrest victims: a retrospective analysis of prehospitalisation records in Kumamoto City

Abstract

Background: Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) is an effective tool for improving the outcome of out-of-hospital cardiac arrest (OHCA) by providing dispatcher assistance (DA) to bystander cardiopulmonary resuscitation (BCPR) and public access defibrillators (PAD). However, it is unclear whether DA-CPR improves the neurological outcomes of OHCA. In this study, we assessed the effectiveness of DA-CPR using prehospitalisation records in Kumamoto City (Japan), which has a population of 730,000, an area of 390 km2, and 25 ambulances. The DA-CPR protocol in Kumamoto City commenced in 2014.

Methods: We retrospectively analysed the prehospitalisation records in Kumamoto City between 2014 and 2016. The cases were divided into two groups according to whether they received DA: DA group and non-DA group. The BCPR and PAD rates were compared between the two groups. The neurological outcomes (Glasgow–Pittsburgh cerebral performance category 1–2) were compared between the two groups by propensity score analysis with inverse probability of treatment weighting.

Results: A total of 1607 prehospitalisation records were identified and divided into the DA (n=1132) and non-DA (n=474) groups. BCPR (72% vs 17%, p<0.001) and PAD (11% vs 5%, p<0.001) rates were greater in the DA group. Propensity score analysis showed that the neurological outcome was significantly better in the DA group (odds ratio 1.718; 95% confidence interval: 1.017-2.902; p=0.0431).Conclusions: DA-CPR was associated with improved BCPR, PAD, and neurological outcomes of OHCA in this analysis of prehospitalisation cases in Kumamoto City.


Authors: Tadashi Kaneko, Hiromichi Tanaka, Keiji Uezono, Ryuichi Karashima, Shinsuke Iwashita, Hiroki Irie, Kazuo Nishioka, Shunji Kasaoka

The accuracy of SIRS criteria, qSOFA and SOFA for mortality suspected sepsis patient admitted to the Intensive Care Unit Dr. Hasan Sadikin General Hospital Bandung, January-December 2017

Abstract

Objective: The high mortality rate found on infectious patients in the intensive care unit (ICU) calls for sepsis identification tools. Sepsis consensus introduced Systemic Inflammatory Response Syndrome (SIRS) criteria, quick Sequential Organ Failure Assessment (qSOFA) score, and Sequential Organ Failure Assessment (SOFA) score. This study aimed at comparing the accuracy and quality to discriminate among the SIRS, qSOFA score, and SOFA score for predicting mortality among patients at risk of sepsis admitted to the ICU.

Design: This study used the analytic observational method with retrospective cohort approach to a sample of 73 qualified medical record data. The data regarding the SIRS, qSOFA, and SOFA criteria were applied after 24 hours of ICU admission.

Setting: ICU of Dr. Hasan Sadikin General Hospital, Bandung from January to December 2017.

Measurements and results: The results of this study showed the SOFA score as being the most accurate and having a good quality to discriminate, with the value of area under the receiver operating characteristic (AUROC) 0.866 (95% CI 0.782-0.95; p=0.00); the qSOFA score had AUROC of 0.707 (95% CI 0.588-0.826; p=0.002) while SIRS criteria were not significant.Conclusions: The conclusion of this study is that in patients with suspected sepsis admitted to an ICU, the SOFA score is the most accurate to predict mortality, whereas qSOFA could be considered and the SIRS criteria is not recommended.


Authors: Tinni T. Maskoen, LS Philip, Indriasari, I. Fuadi

Prediction of optimal right internal jugular vein catheter depth: comparison between Peres’ formula and intracavitary ECG

Abstract

Background: Incorrect central venous catheter (CVC) placement can lead to serious complications. In order to prevent complications, CVC insertion depth can be predicted using Peres’ formula or intracavitary electrocardiography (ECG). The accurate prediction of optimal CVC depth using Peres’ formula and intracavitary ECG on Malay race is unknown.

Objective: To compare the accuracy of Peres’ formula and intracavitary ECG in predicting the optimal depth of right internal jugular venous catheter on adult Malay race.

Methods: This was a comparative analytic observational study with cross sectional design conducted at Cipto Mangunkusumo National General Hospital Jakarta from May to July 2017. After obtaining approval from the local ethical committee, right internal jugular venous catheter insertion was attempted on 111 patients, but 7 subjects were excluded from the study. Statistical analysis was performed on 104 samples to determine the accuracy of CVC depth prediction based on Peres’ formula and intracavitary ECG using McNemar’s test. The CVC depth prediction formula in adult Malay subject was calculated using linear regression based on its correlation with age, height, and body weight.

Results: The accuracy of intracavitary ECG and Peres’ formula to predict the optimal depth of right internal jugular venous catheter was 75% and 11.5%, respectively. The difference between the accuracy of these two methods was statistically significant (p=0.001). Correlation analysis showed a significant relationship between height and the optimal depth of right internal jugular vein catheter. The CVC depth prediction formula obtained in this study was 4.143 + (0.058 x height in cm).Conclusion: Prediction of right internal jugular venous catheter depth using intracavitary ECG is more accurate than the Peres’ formula.


Authors: Aida Rosita Tantri, Aldy Heriwardito, Hana Nur Ramila

Intubation practices at Wellington Hospital Emergency Department: an eight month retrospective observational study

Abstract

Objective: To determine the rate of intubations carried out in Wellington Hospital Emergency Department (tertiary hospital), New Zealand, to provide a description of intubating habits of clinicians including operator experience and methods, and to determine the rate of complications.

Design: Eight month, retrospective, observational study.

Setting: Wellington Hospital Emergency Department(WHED).

Location: New Zealand.

Patients and participants: All patients intubated in the Emergency Department were included.

Interventions: None. Audit related activity.

Measurements and results: Over the eight months 57 intubations occurred. The most common indications for intubation were head injury with reduced Glasgow Coma Scale (GCS) and overdose (both 18.9%) followed by stroke, seizure and cardiac arrest (9.4-11.3%). Most intubations (46%) occurred between 8 a.m.-5 p.m. Eighty-two point seven percent of patients were intubated by ED doctors where seniority of team leader and intubating doctor varied according to the time of day. Intubation was consultant led 68.4% of the time before 5 p.m. and 40% of the time overnight. Airway checklist use was reported in 54.5% with formal airway assessment documented in 50%. Successful first pass occurred in 77.2% of cases. Difficult laryngoscopy (grade 3-4) was reported in 16.6% using direct laryngoscopy and 18.8% using videolaryngoscopy. All patients were successfully intubated orally in 3 attempts or less. Etomidate was drug of choice (54.7%). Seventeen point five percent experienced one or more complications. Trends towards less complications related to direct laryngoscopy compared to videolaryngoscopy and use of cricoid pressure associated with a higher complication rate were noted. However there were low numbers and statistical significance was not reached.

Conclusion: The first pass success rate for intubation was lower in comparison to other studies although adverse event rate was also lower. As a high-risk procedure, an incidence of seven intubations per month highlights the need for more diverse training opportunities for skills maintenance.


Authors:

Toward having safe environment in critical care units: a multisite study

Abstract

Objective: This study was conducted to assess the safety culture in Jordanian intensive care units.

Design: The study was descriptive, cross-sectional design, and multisite.

Setting: The Safety Attitude Questionnaire-Intensive Care Unit (SAQ-ICU) version was utilized. Three hundred completed questionnaires were returned from four critical care units.

Results: The results offered a fundamental element for further research on safety matter in Jordanian ICUs. Many recommendations were highlighted by the Jordanian nurses in order to improve the safety culture in the ICUs including standard nurse-patients ratio, good communication and collaboration between health professionals, enhance continuing education and training. To the knowledge, this is the first study conducted in Jordan using the SAQ to examine nurses’ safety culture attitudes in Jordanian ICUs.

Conclusion: The present findings provide a baseline for future research aiming for improving the quality of care in Jordanian ICUs.


Authors:

Barriers to effective in-hospital resuscitation: lessons learned during implementation of a hospital-wide code system

Abstract

Aims and objectives: To understand the barriers involved in effecting a hospital-wide code system and overcoming them during implementation.

Background: Improving survival after in-hospital cardiac arrest involves standardization of both defibrillation equipment and staff's abilities during codes.

Design: Observational descriptive study.

Methods: Observational study of the situation existing before implementation of an effective in-hospital resuscitation system and description of the implementation process. Descriptive statistics were used.

Results: Prior to intervention, defibrillators were unstandardized, misused and often inaccessible. Basic and advanced life support training was suboptimal and poorly overseen. Codes were attended by curious bystanders and inappropriate staff; there was lack of clarity regarding roles and key interventions. A standard defibrillator model was purchased and gradually deployed throughout the hospital; these were configured to meet the unique requirements of each department. Training was restructured. Standard operating procedures were created for all resuscitations while an oversight mechanism was installed. Code teams were created by taking departmental workloads and clinical skills into consideration. A nurse resuscitation coordinator was appointed per department and a hospital-wide culture was fostered where nurses were responsible for the quality of CPR. Major limiting issues such as distrust of device accuracy and safety, knowledge gaps and problems at the device-user interface were identified and bridged.

Conclusions: Creation of an effective in-hospital code system requires thorough research into the culture and requirements of various hospital departments. Multiple barriers must be overcome to set this process into motion.

Relevance to clinical practice: Implementation of change requires more than a declaration from supervisors; it requires deep understanding of the existing culture of different departments to take effective root. Awareness of these often unacknowledged issues combined with the willingness to confront and overcome them are keys to success.


Authors:

Medication incompatibility in intravenous lines in a Paediatric Intensive Care Unit (PICU) of Indonesian hospital

Abstract

Objectives: Currently, little is documented concerning the patterns of multiple concurrent medication use utilising single intravenous line. The in-line compatibility issues in Paediatric Intensive Care Units (PICUs) are not as well documented as in adult patients either. This study closely examined the combination of medications used concurrently in a PICU, recorded how medications were used, and then investigated the in-line potential compatibility.

Methods: This study was a mixed model designed first to identify retrospectively the patterns of multiple medication use at any single time of administration (STA). Secondly, a questionnaire was distributed to practitioners to elucidate their perceptions about incompatibility.

Results: From a single lumen peripheral line in-vitro simulation, it was observed that three infusions typically met in sequential Y-sites and had the potential to interact. The combinations identified were morphine+midazolam, midazolam+fentanyl+morphine, morphine+fentanyl+dobutamine, morphine+midazolam+ketamine, and midazolam+dobutamine+norepinephrine. Compatibility data covering simultaneous administration of three-or-more intravenous drugs was not found in 97.5% (n=120) of the cases. Most practitioners (92.9%) recognized incompatibility. Many (46.4%) said they observed >3-10 in-line incompatibilities in a month. Most nurses (78.5%) reported using the manufacturer as their reference source for compatibility data. Flushing with clear fluid between doses was the most used method to prevent incompatibility (45.5%).

Conclusions: It was a common practice to concurrently administer three or more medications: analgesics, sedatives, inotropes, and others, through the same port with major potential for incompatibility issues. Most of the literature is based on two drug comparisons with minimal information on using combinations of three or more. Most practitioners’ understanding of the implications of the terminology of “incompatibility not known or possible” for their patients appeared lacking.


Authors:

Association of vitamin D plasma concentration with the severity of illness among children with sepsis treated in Pediatric Intensive Care Unit

Abstract

Objective: To investigate whether vitamin D plasma concentration correlated with the severity of illness in sepsis children treated in a Pediatric Intensive Care Unit (PICU).

Design: This was a cross sectional study.

Settings: Pediatric Intensive Care Unit of Sanglah Hospital Denpasar, Bali, in May to November 2016.

Patients and participants: Samples were patients aged 28 days to 12 years who had sepsis or severe sepsis or septic shock and have been hospitalized in PICU. The subjects who met the inclusion criteria were divided into two groups based on the vitamin D status: normal and insufficient.

Intervention: The severity of illness of the patients in each group was measured using Pediatric Logistic Organ Dysfunction (PELOD) II and Pediatric Risk of Mortality (PRISM) III score. The demographic data, anthropometric status, and severity of the illness were taken from the medical records. The amount of sun exposure and patient nutritional intake were taken from questionnaires answered by the parents.

Results: A total of 48 patients were examined in this study. Bivariate analysis showed that vitamin D insufficiency was associated with a higher severity of sepsis based on the PRISM III (r=-0.44, p=0.006) and PELOD score (r=-0.5, p<0.001).

Conclusion: Vitamin D plasma concentration was negatively correlated with the illness severity in children with sepsis.


Authors: