Ethambutol-induced nephrotoxicity: case report and review of the literature

Ethambutol is a common component in the treatment of mycobacteria infections worldwide, and is rarely associated with nephrotoxicity. We report a patient presenting with acute kidney injury due to ethambutol as well as its management and a comprehensive review of the pertinent literature.Ethambutol-induced nephrotoxicity- case report and review of the literature


Clinical application, the use of dexmedetomidine in intensive care sedation

Sedation and analgesia are common interventions in intensive care and constitute an integral part of the care of critically ill patients. However, there is no consensus on the best combination of agents or strategies to manage sedation and analgesia effectively and safely, and in particular in patients who need prolonged mechanical ventilation.
The current Clinical Practice Guidelines for the provision of sedation and analgesia in critically ill adults were drafted in 2002 and are supported by studies that largely apply to a North American practice of intensive care rather than an Australasian practice. (1) Benzodiazepines and other gamma-aminobutyric acid (GABA)


The Use of APRV and Open Lung Management for Improving the Outcome of Lung Procurement for Transplantation

One of the most difficult organs to procure for donation is the lung. A detailed understanding of the physiology of mechanical ventilation and its effect on donor lungs is needed to impact on the outcome of lung transplantation. An organized protocol for mechanical ventilation management of the organ donor using the Open Lung Model may positively affect the number of organs that can be procured, and the function of these organs post transplant.
Based on physiologic principles, the use of new modes of ventilation may affect the modulation of cytokines, decrease the transmigration of organisms into the donor lung, ...


Critical Care Economics

Health care costs represent a large percentage of the gross domestic product all over the world. According to the National Health Statistics Group, health care expenditure in the United States accounted for as much as 14% of the gross national product in 1992 and it is projected to reach 30% by 2030.
The intensive care unit (ICU) represents the hallmark of highly competent modern hospitals, offering highly trained staff and life-saving technology and it is also one of the most expensive units in the hospital.
Expenses related to running the ICU have been estimated at approximately 20% of total hospital costs, despite only representing 10% of all hospital beds.
Assisted mechanical ventilation particularly affects the high costs in the ICU. Actually, a mere of 1 million persons per year receive mechanical ventilation during their stay in the ICU. A variety of different approaches to stabilize or reduce costs in ...


Exercise-Associated Hyponatremia and the Varon-Ayus Syndrome

Endurance sports such as marathon running are increasingly popular, attracting both professional and recreational athletes. While most participants recognize that these events can result in health hazards, few consider death a likely outcome. Exercise associated hyponatremia can be a consequence for which fatal outcomes may occur. In some it is mild and without symptoms. However, in others it is of such severity that respiratory failure secondary to pulmonary edema, and possibly death may result. This article reviews new information regarding predisposing factors, treatment, and outcomes associated with exercise induced hyponatremia and the Varon-Ayus syndrome (hyponatremia, pulmonary edema and cerebral edema associated to marathon running).


Airway Pressure Release Ventilation (APRV) for the Treatment of Severe Life-Threatening ARDS in a Morbidly Obese Patient

Airway pressure release ventilation (APRV) is a relatively new mode of ventilation that became commercially available in the United States in the mid-1990s. APRV differs fundamentally from that of conventional positive-pressure ventilation. Whereas conventional modes of ventilation begin the ventilatory cycle at a baseline pressure and elevate airway pressure to accomplish tidal ventilation, APRV commences at an elevated baseline pressure and follows with a deflation to accomplish tidal ventilation (Figure 1) [1]. The elevated baseline pressure facilitates oxygenation and lung recruitment while the timed releases aids in carbon dioxide removal. Advantages of APRV include lower airway pressures, lower minute ventilation, minimal adverse effects on cardio-circulatory function, ability to spontaneously breathe throughout the entire ventilatory cycle and decreased need for sedation. APRV is consistent with lung protection strategies that strive to limit lung injury associated with mechanical ventilation. APRV is a recognized mode of ventilation in trauma patients with acute respiratory distress syndrome (ARDS) [2]. However, its adoption in the medical ICU has been limited. We report the case of a morbidly obese patient who developed aspiration pneumonitis and severe life-threatening ARDS who was successfully managed with APRV.

Case report
A 25 year-old African-American male presented to hospital for ophthalmic surgery for retinal detachment of his right eye. His past medical history was signifi cant for asthma, morbid obesity (BMI of 53.2 kg/m2), and obstructive sleep apnea. During anesthesia his airway was “secured” with a laryngeal mask (LMA). In the immediate post-operative period, he developed respiratory distress which was treated with supplemental oxygen as well as methylprednisolone, furosemide, and nebulized bronchodilators. He was transferred to the medical intensive care unit (MICU) with respiratory distress, progressive hypoxemia and hypotension requiring fl uid resuscitation and endotracheal intubation (approximately 6 hours after surgery) with assisted mechanical ventilation. On presentation to the ICU his temperature was 98oF, heart rate 120 beats per minute, blood pressure 90/60 mmHg, respiratory rate 30 breaths per minute with an oxygen saturation of 88% on a rebreathing mask. Physical examination was notable for morbid obesity, coarse breath sounds on lung auscultation and bilateral lower extremity pitting edema. On admission white blood cell was 31x109/l with 90% neutrophils, creatinine was 2.1 mg/dl and lactate was 6.7 mmol/l (67.4 mg/dl). Arterial blood gas analysis on assistcontrolled ventilation with a tidal volume 750 ml (9 ml/kg ideal body weight of 80kg), respiratory rate of 20/minute, PEEP of 5 cmH2O and FiO2 of 1.0 was pH 7.22, PaCO2 58 mmHg and PaO2 of 82 mmHg with an oxygen saturation of 94%. The chest radiograph revealed diffuse bilateral alveolar airspace disease (Figure 2). The presumptive diagnosis was acid aspiration pneumonitis causing ARDS (Mendelsohn’s syndrome) [3]. The patient developed progressive hypoxia despite increasing PEEP to 16 cmH2O with repeat blood gas analysis demonstrating a pH of 7.21, PaCO2 of 49 mmHg, PaO2 of 50 mmHg with an oxygen saturation of 84%. At this point the patient was switched to APRV (Puritan-Bennett 940® ventilator) with the following settings: PEEP-high 35 cmH2O, PEEP-low 5 cmH2O, release rate of 12/minute, time-low of 0.8 s, pressure support of 5 cmH2O above PEEP-high and a FiO2 of 100%. Within hours of changing to APRV we noted signifi cant improvement in oxygenation, a decrease in dead space ventilation ratio from 0.7 to 0.46 (NICO® Vd/Vt) with minimal change in PaCO2. Repeat chest radiograph was markedly improved (Figure 3). The change in the PaO2/FiO2 and PaCO2 over time is illustrated in Figure 4. A transthoracic echocardiogram demonstrated normal cardiac size and function while lower extremity venous Doppler examination was normal. Additional treatment included a hydrocortisone infusion at 10 cc/hr (for 7 days followed by a steroid taper), enoxaparin at prophylactic dose (40 mg SC daily) and enteral nutrition (Oxepa, Ross/Abbott Laboratories, Chicago, IL). Vancomycin and piperacillin/tazobactam initiated for treatment of presumed sepsis were discontinued once the mini-bronchoalveolar lavage and all other cultures were negative. The patient had a prolonged stay in ICU, being liberated from mechanical ventilation after 13 days of APRV. The remainder of his hospital course was uneventful; he was discharged after 20 days of hospitalization.

ARDS is a frequent cause of admission to the ICU. The current standard ventilatory mode for patients with ARDS is volume-controlled ventilation using a low-tidal volume lung protective strategy (6 ml/kg ideal body weight) [4]. In a subset of patients with severe ARDS such a ventilatory strategy may be unable to maintain adequate arterial oxygenation and ventilation. APRV has been used in trauma patients as a rescue mode to improve oxygenation in patients failing assist-control mode [2]. There is limited data on the use of APRV in medical patients with severe ARDS. APRV may be particularly useful in patient with morbid obesity. We believe that the use of APRV in our patient was a life saving intervention. APRV, fi rst described by Stock and Downs in 1987 [5], is a time-triggered, pressure-limited, time-cycled mode of ventilation that allows unrestricted spontaneous breathing throughout the entire ventilatory cycle. The patient’s spontaneous breaths are unrestricted and independent of the ventilator cycle. APRV helps to meet the goals of ARDS management by maximizing alveolar recruitment [6] while limiting the transalveolar pressure gradient and barotrauma. APRV is very well tolerated by patients allowing minimal sedation with spontaneous breathing which improves V/Q mismatching and cardiac performance [7,8]. The reduced need for sedative agents as compared to other modes of advanced ventilation is a very important attribute of APRV, as the use of sedative agents has been liked to prolonged ICU stays, delirium and ncreased risk of complications. Morbid obesity has signifi cant effects on the respiratory system which impacts the ventilatory management of these patients. The expiratory reserve volume (ERV) declines signifi cantly with increasing BMI. The fall in ERV is presumably due to small airway closure particularly in the dependent areas of the lung. The vital capacity (VC), total lung capacity (TLC) and functional residual volume (FRV) are generally maintained in otherwise normal individuals with mild to moderate obesity but are reduced by up to 30% in morbidly obese patients [9-10]. In addition, the mechanical effect of obesity causes a decrease in chest wall compliance. The effects of obesity on the respiratory system are compounded in patients with acute lung injury, consequently the standard approach to ventilatory support with low-tidal volumes may result in severe lung derecruitment and inadequate ventilation. APRV may be the ideal ventilatory mode in obese patients with severe ARDS as the increased mean alveolar pressure with short release time will recruit collapsed lung while preventing over-distension of ventilated alveoli. In our institution, we use a step-wise strategy to liberate patients from mechanical ventilation when on the APRV mode. First we decrease FiO2 followed by the PEEP-high. Should the patient tolerate the decrease in FiO2 and PEEP-high, we then increase time-low with further reductions in the PEEP-high until we reach a CPAP (PEEP-low) of 5 cmH2O. At this point we increase the pressure support to 10 cmH2O followed by extubation if the patient is comfortable on these settings. It is very important to stress that the PEEPhigh should be reduced in increments of no greater than 3 cmH2O at an interval no more frequently than every 8-12 hours. Severe (and irreversible) derecruitment may occur if PEEP-high is weaned to rapidly.
In summary, we believe that APRV should be considered in patients with severe ARDS who tolerate low-tidal volume assist controlled ventilation poorly. APRV may be particularly useful in the management of obese patients with ARDS.