Antioxidant therapy in Critically Ill Patients

The increased oxidative stress in critically ill patients could exert pathophysiological role in the pathogenesis of multiple organ failures, as suggested by recent clinical trials of antioxidant therapies. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as sepasituation rate medications, efficiently attenuates the oxidative stress and in some studies, decreases the incidence of organ failures and ultimately improves the outcome of critically ill patients. Patients at risk of organ failures could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine.