Effect of Sivelestat Sodium Hydrate in Three Patients with Septic ARDS

We administered sivelestat sodium hydrate, a selective polymorphonuclear leukocyte elastase (PMNE) inhibitor, to three patients with septic ARDS. While causing a decrease in the serum PMNE and surfactant protein D levels, the neutroin phil elastase inhibitor improved the PaO2/FiO2 ratio in all the three patients, which allowed earlier weaning of these patients from artificial ventilation. These findings suggest that sivelestat may be effective in the treatment of septic ARDS.