Hypoxic tissue damage and the protective effects of therapeutic hypothermia

Several molecules, chemicals and cells are involved in tissue damage during any hypoxic event, such as a cardiac arrest, a respiratory arrest or a cerebrovascular accident. Among them: calcium, protein kinase enzymes, calcium binding proteins, S-100â protein and adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1) are frequently cited in the literature. Controversy exists as to whether these “hypoxic aggressors” can be modified favorably by the use of therapeutic hypothermia. This review focus on the role of these different molecules, chemicals and cells and the protective effect of therapeutic hypothermia.