Role of lipids in sepsis

Activation of phospholipase A2, excess formation of proinflammatory eicosanoids, decreased generation of lysophosphatidylcholine (LPC) and enhanced lev- Address requests for reprints to: Undurti N Das, MD, FAMS, FICP., UND Life Sciences, 1083, Main Street, Walpole, MA 02081, USA Tel. : 508-668-5324, Fax. : 928-833-0316 E- mail: els of ceramide play a significant role in sepsis. This suggests that lipids participate in the pathogenesis of sepsis.