Sepsis: A Study of Physician’s Knowledge about the Surviving Sepsis Campaign in Puerto Rico

Sepsis is a clinical syndrome characterized by systemic inflammation and widespread tissue injury. It results from an excessive inflammatory host response to an infective agent which, when generalized, involves normal tissue not originally affected by the causative organism(s). There is massive release of inflammatory mediators, causing leukocytes to accumulate in organs distant from the initial infection, with further inflammation. Recent evidence recognizes the active role of a deregulated coagulation cascade in the pathophysiology of sepsis. These changes result in severe alterations of the microcirculation with the end result being tissue hypoperfusion.