Ventilation-Induced Lung Injury and Its Prevention

The influence of detrimental forms of mechanical ventilation on the fluid balance across the alveolo-capillary barrier and its influence on the surfactant system have been extensively described in literature. Moreover, possible mechanisms by which such ventilation strategies exert systemic effects and effects on other organs are becoming increasingly realized. This paper describes the complications of detremental forms of mechanical ventilation and the physiological background to prevent such complications.