Increased serum cystatin C is a predictive factor for renal outcome in non-cardiac critically ill patients

Cystatin C is a 122-amino-acid, 13 kDa protein that is a member of the family of competitive inhibitors of lysosomal cysteine proteinases. (1) Serum cystatin C is a useful tool employed in cardiac disease patients to measure kidney function, (2,3) and it may be a risk factor for cardiac events, including heart failure, coronary artery disease, and diastolic dysfunction, with or without chronic heart disease. (4-11) The estimated glomerular filtration rate (eGFR) of serum creatinine is also an established tool employed in measuring kidney function in cardiac disease patients. (12)
More than 30% of critically ill patients exhibit acute kidney