Clinical application, the use of dexmedetomidine in intensive care sedation

Sedation and analgesia are common interventions in intensive care and constitute an integral part of the care of critically ill patients. However, there is no consensus on the best combination of agents or strategies to manage sedation and analgesia effectively and safely, and in particular in patients who need prolonged mechanical ventilation.
The current Clinical Practice Guidelines for the provision of sedation and analgesia in critically ill adults were drafted in 2002 and are supported by studies that largely apply to a North American practice of intensive care rather than an Australasian practice. (1) Benzodiazepines and other gamma-aminobutyric acid (GABA)