CVVHD, impedance cardiography and critical care nephrology: a case study of chronic myeloid leukemia-associated ARF

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by clonal expansion of myeloid cells, with the aberrant BCR-ABL fusion gene as the pathognomonic cytogenetic anomaly. (1) Leukemic cells are minimally invasive and their proliferation is largely confined to hematopoietic tissues: primarily to the blood, bone marrow, spleen and liver. (2) Although rare, renal involvement in CML has also been reported. (3-5)
In addition to parenchymal infiltration of leukemia cells, CML can adversely impact on the kidneys in several ways. (4) Acute renal failure (ARF) of the renal origin, in turn, is associated with increased hospital mortality of CML patients. (6)