Statin use and morbidity outcomes in septic shock patients: a retrospective cohort study

Sepsis is a significant burden on the health care system and is among the top ten leading causes of death in the United States. (1) The incidence of sepsis is rising substantially due to an aging population, increasing resistance among microorganisms, higher prevalence of immunocompromised patients, increasing number of patient comorbidities and more high risk surgeries being performed. One in four cases of sepsis progresses to severe sepsis or septic shock, conditions characterized by organ dysfunction and hypotension. (2) Septic shock carries a high mortality rate, adversely affects quality of life after hospital discharge and is a significant financial burden to the health care system.