Sepsis-induced T-cell suppression in pediatric sepsis

Abstract

Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resuscitation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Recent hypothesis suggests host’s immune response pathology in the form of compensatory anti-inflammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity.

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